Abstract
20 consecutive adult patients with acute lymphoblastic leukemia were treated with an intense induction regimen including vincristine, doxorubicin, prednisolone, L-asparaginase and cyclophosphamide. 16 patients (80%) achieved complete remission and were then given CNS prophylaxis and 3 years of maintenance therapy. With minimum follow-up of 24 months, the median duration of first remission is 37+ months. Out of 10 patients who have completed maintenance therapy, 2 have relapsed after 14 and 22 months, respectively, and 7 are in continuous complete remission 1+-55+ months off therapy.
MeSH terms
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Adolescent
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Asparaginase / administration & dosage
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Asparaginase / adverse effects
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Blood Transfusion
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Cyclophosphamide / administration & dosage
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Cytarabine / administration & dosage
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Doxorubicin / administration & dosage
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Drug Evaluation
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Humans
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Meningeal Neoplasms / prevention & control
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Mercaptopurine / administration & dosage
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Methotrexate / administration & dosage
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Middle Aged
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Nervous System Diseases / chemically induced
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
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Prednisolone / administration & dosage
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Prednisolone / adverse effects
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Remission Induction
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Vincristine / administration & dosage
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Vincristine / adverse effects
Substances
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Cytarabine
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisolone
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Mercaptopurine
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Asparaginase
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Methotrexate