Inferring Plasmodium vivax protein biology by using omics data

J Proteomics. 2020 Apr 30:218:103719. doi: 10.1016/j.jprot.2020.103719. Epub 2020 Feb 21.

Abstract

Deciphering Plasmodium vivax biology has long been a challenge for groups working on this parasite, mainly due to the complications involved in propagating it in vitro. However, adapting P. vivax strains in non-human primates and the arrival of high-performance analysis methods has led to increased knowledge regarding parasite protein composition and the ability of some molecules to trigger an immune response or participate in protein-protein interactions. This review describes the state of the art concerning proteomics-, immunomics- and interatomics-related P. vivax omic studies, discussing their potential use in developing disease control methods.

Keywords: Control methods; Immunomics; Interactomics; Plasmodium vivax; Proteomics.

Publication types

  • Review

MeSH terms

  • Animals
  • Malaria, Vivax*
  • Plasmodium vivax*
  • Proteomics
  • Protozoan Proteins

Substances

  • Protozoan Proteins