Cloning and sequencing of a beta-thalassemia gene from south China

T Wang; X Y Zhou; S Huang; S W Wang; R L Cai; G Y Liu; S R Yang; W H Lo

doi:10.3109/03630268808991652

Cloning and sequencing of a beta-thalassemia gene from south China

Hemoglobin. 1988;12(5-6):615-9. doi: 10.3109/03630268808991652.

Authors

T Wang¹, X Y Zhou, S Huang, S W Wang, R L Cai, G Y Liu, S R Yang, W H Lo

Affiliation

¹ Department of Medical Genetics, Peking Union Medical College, Beijing, P.R. China.

PMID: 3209403
DOI: 10.3109/03630268808991652

Abstract

A beta-thalassemia gene from a patient with beta+-thalassemia in South China was cloned and sequenced. A four nucleotide (TCTT) deletion in codons 41 and 42 was found. This is the most common beta-thalassemia gene in South China and the first mutant identified on China mainland.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
China
Chromosome Deletion
Cloning, Molecular*
Humans
Infant
Male
Molecular Sequence Data
Mutation
Thalassemia / genetics*