Boron-11 MRI and MRS of intact animals infused with a boron neutron capture agent

Magn Reson Med. 1988 Oct;8(2):231-7. doi: 10.1002/mrm.1910080214.

Abstract

Boron neutron capture therapy (BNCT) depends on the delivery of boron-containing drugs to a targeted lesion. Currently, the verification and quantification of in vivo boron content is a difficult problem. Boron-11 spectroscopy was utilized to confirm the presence of a dimeric sulfhydryl dodecaborane BNCT agent contained in an intact animal. Spectroscopy experiments revealed that the decay time of transverse magnetization of the boron-11 spins was less than 1 ms which precluded the use of a 2DFT imaging protocol. A back-projection protocol was developed and utilized to generate the first boron-11 image of a BNCT agent in the liver of an intact Fisher 344 rat.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Borates / analysis*
  • Borates / therapeutic use
  • Liver / analysis*
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Neutrons*
  • Radiotherapy / methods
  • Rats
  • Rats, Inbred F344
  • Sulfides / analysis*
  • Sulfides / therapeutic use

Substances

  • Borates
  • Sulfides
  • cesium 1,1'-dithiobis(undecahydrododecaborate)