Glucose abnormalities detected by continuous glucose monitoring are common in young children with Cystic Fibrosis

Bernadette J Prentice; Chee Y Ooi; Charles F Verge; Shihab Hameed; John Widger

doi:10.1016/j.jcf.2020.02.009

Glucose abnormalities detected by continuous glucose monitoring are common in young children with Cystic Fibrosis

J Cyst Fibros. 2020 Sep;19(5):700-703. doi: 10.1016/j.jcf.2020.02.009. Epub 2020 Feb 25.

Authors

Bernadette J Prentice¹, Chee Y Ooi², Charles F Verge³, Shihab Hameed⁴, John Widger⁵

Affiliations

¹ Department of Respiratory Medicine, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, Medicine, The University of New South Wales, Randwick, NSW, Australia; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), Sydney, Australia. Electronic address: [email protected].
² School of Women's and Children's Health, Medicine, The University of New South Wales, Randwick, NSW, Australia; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), Sydney, Australia; Department of Gastroenterology, Sydney Children's Hospital, Randwick, NSW, Australia.
³ School of Women's and Children's Health, Medicine, The University of New South Wales, Randwick, NSW, Australia; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), Sydney, Australia; Department of Endocrinology, Sydney Children's Hospital, Randwick, NSW, Australia.
⁴ School of Women's and Children's Health, Medicine, The University of New South Wales, Randwick, NSW, Australia; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), Sydney, Australia; Department of Endocrinology, Sydney Children's Hospital, Randwick, NSW, Australia; Faculty of Medicine, University of Sydney, NSW, Australia.
⁵ Department of Respiratory Medicine, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, Medicine, The University of New South Wales, Randwick, NSW, Australia; Molecular and Integrative Cystic Fibrosis Research Centre (miCF_RC), Sydney, Australia.

PMID: 32111453
DOI: 10.1016/j.jcf.2020.02.009

Abstract

It is not yet known whether continuous glucose monitoring (CGM) abnormalities persist in young children with CF. We evaluated longitudinal CGM results for children with CF < 10 years of age. We performed 3-day CGM at baseline, 12 months, and 24 months on 11 CF children (1 female) initially aged mean (SD) 3.8 (2.5) years. CGM analysis included (i) mean sensor glucose (SG), (ii) standard deviation (SD) for SG, (iii) peak SG and (iv)% time spent above a threshold of 7.8 mmol/L. Only three (3/11, 27%) had normal CGM at all time-points. Nearly three quarters of the participants (8/11, 73%) spent more than 4.5 percent time > 7.8 mmol/L at one time-point, five of whom had an elevated percent time on a subsequent test. Young children with CF have glucose abnormalities detected by CGM that fluctuate over time.

Keywords: Child; Cystic Fibrosis; Cystic Fibrosis-related diabetes; Diabetes; Glucose.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Blood Glucose Self-Monitoring
Child
Child, Preschool
Cystic Fibrosis / complications*
Cystic Fibrosis / metabolism*
Extracellular Fluid / metabolism
Female
Glucose / metabolism
Glucose Intolerance / diagnosis*
Glucose Intolerance / etiology
Glucose Intolerance / metabolism
Humans
Longitudinal Studies
Male
Prospective Studies
Time Factors

Substances

Glucose