Post tuberculosis treatment infectious complications

Desmond Hsu; Muhammad Irfan; Kauser Jabeen; Nousheen Iqbal; Rumina Hasan; Giovanni Battista Migliori; Alimuddin Zumla; Dina Visca; Rosella Centis; Simon Tiberi

doi:10.1016/j.ijid.2020.02.032

Post tuberculosis treatment infectious complications

Int J Infect Dis. 2020 Mar:92S:S41-S45. doi: 10.1016/j.ijid.2020.02.032. Epub 2020 Feb 27.

Authors

Affiliations

¹ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Department of Infection, Royal London Hospital, Barts Health NHS Trust, London, UK. Electronic address: [email protected].
² Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan. Electronic address: [email protected].
³ Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan. Electronic address: [email protected].
⁴ Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan. Electronic address: [email protected].
⁵ Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan. Electronic address: [email protected].
⁶ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. Electronic address: [email protected].
⁷ Division of Infection and Immunity, University College London and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK. Electronic address: [email protected].
⁸ Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy; Department of Medicine and Surgery, Respiratory Diseases, University of Insubria, Varese, Italy. Electronic address: [email protected].
⁹ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. Electronic address: [email protected].
¹⁰ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Department of Infection, Royal London Hospital, Barts Health NHS Trust, London, UK. Electronic address: [email protected].

PMID: 32114203
DOI: 10.1016/j.ijid.2020.02.032

Abstract

Following greater attention and follow-up of patients with treated pulmonary tuberculosis (TB), it has emerged that infections are more likely to occur in this cohort of patients. This comes as no surprise, as pulmonary TB is a destructive process that leads to cicatrization, alteration of parenchyma, bronchiectasis, and scarring of the lung, with reduction of lung volumes and an impact on pulmonary function. In addition to relapse and re-infection with TB, other pathogens are increasingly recognized in post-TB patients. This paper serves as a summary and guide on how to approach the post-TB patient with new signs and symptoms of pulmonary infection in order to ensure optimal management and rehabilitation.

Keywords: Bronchiectasis; NTM; Post-treatment complication; Pulmonary rehabilitation; Sequelae; Tuberculosis.

Publication types

Review

MeSH terms

Bronchiectasis / etiology
Coinfection
Humans
Recurrence
Respiratory Tract Infections / drug therapy*
Respiratory Tract Infections / etiology
Tuberculosis, Pulmonary / complications*