Targeting Treatment Refractory NET by EZH2 Inhibition in Postural Tachycardia Syndrome

Harikrishnan Kaipananickal; Abdul Waheed Khan; Jun Okabe; Susan J Corcoran; Murray D Esler; Assam El-Osta

doi:10.1161/CIRCRESAHA.119.315654

Targeting Treatment Refractory NET by EZH2 Inhibition in Postural Tachycardia Syndrome

Circ Res. 2020 Apr 10;126(8):1058-1060. doi: 10.1161/CIRCRESAHA.119.315654. Epub 2020 Mar 3.

Authors

Harikrishnan Kaipananickal^#^{1

2

3}, Abdul Waheed Khan^#^{1

2}, Jun Okabe^{1

2

3}, Susan J Corcoran⁴, Murray D Esler⁴, Assam El-Osta^{1

2

3

4

5

6

7

8}

Affiliations

¹ From the Epigenetics in Human Health and Disease Laboratory (H.K., A.W.K., J.O., A.E.-O.), Monash University, Melbourne, Australia.
² Department of Diabetes, Central Clinical School (H.K., A.W.K., J.O., A.E.-O.), Monash University, Melbourne, Australia.
³ Department of Clinical Pathology, The University of Melbourne, Parkville, Australia (H.K., J.O., A.E.-O.).
⁴ Baker Heart and Diabetes Institute, Melbourne, Australia (S.J.C., M.D.E., A.E.-O.).
⁵ Department of Medicine and Therapeutics (A.E.-O.), The Chinese University of Hong Kong.
⁶ Hong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital (A.E.-O.), The Chinese University of Hong Kong.
⁷ Li Ka Shing Institute of Health Sciences (A.E.-O.), The Chinese University of Hong Kong.
⁸ Department of Technology, Faculty of Health, University College Copenhagen, Biomedical Laboratory Science, Denmark (A.E.-O.).

^# Contributed equally.

PMID: 32122262
DOI: 10.1161/CIRCRESAHA.119.315654

No abstract available

Keywords: epigenetic; heart rate; histone; lysine; nervous system; norepinephrine; postural tachycardia syndrome.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Dose-Response Relationship, Drug
Drug Delivery Systems / methods*
Enhancer of Zeste Homolog 2 Protein / antagonists & inhibitors*
Enhancer of Zeste Homolog 2 Protein / metabolism*
Heart Rate / drug effects
Heart Rate / physiology
Histone Deacetylase Inhibitors / administration & dosage
Humans
Indoles / administration & dosage
Norepinephrine Plasma Membrane Transport Proteins / metabolism*
Nylons
Postural Orthostatic Tachycardia Syndrome / drug therapy
Postural Orthostatic Tachycardia Syndrome / metabolism*
Pyridones / administration & dosage
Pyrroles / administration & dosage

Substances

GSK-2816126
Histone Deacetylase Inhibitors
Indoles
Norepinephrine Plasma Membrane Transport Proteins
Nylons
Pyridones
Pyrroles
SAHA-PIP-delta
SLC6A2 protein, human
EZH2 protein, human
Enhancer of Zeste Homolog 2 Protein