Extensive GTPase crosstalk regulates Golgi trafficking and maturation

Laura L Thomas; J Christopher Fromme

doi:10.1016/j.ceb.2020.01.014

Extensive GTPase crosstalk regulates Golgi trafficking and maturation

Curr Opin Cell Biol. 2020 Aug:65:1-7. doi: 10.1016/j.ceb.2020.01.014. Epub 2020 Mar 3.

Authors

Laura L Thomas¹, J Christopher Fromme²

Affiliations

¹ Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
² Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: [email protected].

Abstract

Virtually all transport events at the Golgi complex are regulated by Arf and Rab family GTPases. Recent work has advanced our knowledge regarding the mechanisms controlling GTPase activity, and it has become clear that GTPases do not act in isolation but rather function in complex networks of crosstalk and feedback. Together with earlier findings, these recent studies indicate that communication between GTPases, their regulatory proteins, effectors, and lipids plays a pivotal role in Golgi transport and cisternal maturation.

Keywords: GTPase; Golgi; Signaling; Trafficking.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Cell Membrane / metabolism
GTP Phosphohydrolases / metabolism*
Golgi Apparatus / metabolism*
Humans
Models, Biological
Phosphorylation
Protein Transport

Substances

GTP Phosphohydrolases

Abstract

Publication types

MeSH terms

Substances

Grants and funding