A Ca-deficientca-deficient hydroxyapatite (CDHA)/MgF2 bi-layer coating with unique nano-scale topography on biodegradable high-purity Mg

Colloids Surf B Biointerfaces. 2020 Jun:190:110911. doi: 10.1016/j.colsurfb.2020.110911. Epub 2020 Feb 27.

Abstract

Enhanced corrosion resistance and accelerated new bone formation are desired to make Mg and its alloys to be ideal candidate for bone biomaterial. For this purpose, a CDHA/MgF2 bi-layer coating was prepared on high purity Mg by a combination of fluoride treatment and hydrothermal treatment. The coating exhibited a nanoscale surface topography. Enhanced adhesion strength and corrosion resistance was obtained for the CDHA/MgF2 bi-layer coating. In vitro cell experiment showed that the adhesion, proliferation and differentiation of MG63 cells were significantly improved on Mg with CDHA/MgF2 coating compared to that on Mg with HA coating and MgF2 coating. In conclusion, this study provides a promising surface modification method for Mg metal with enhanced corrosion resistance and superior osteogenic bioactivity.

Keywords: Biodegradable Mg; CDHA/MgF(2)bi-layer coating; Corrosion resistance; Nanorod-like morphology; Osteogenic capability.

MeSH terms

  • Calcium / chemistry*
  • Cell Adhesion
  • Cell Differentiation
  • Cell Line
  • Cell Proliferation
  • Coated Materials, Biocompatible / chemistry*
  • Durapatite / chemistry*
  • Fluorides / chemistry*
  • Humans
  • Magnesium / chemistry
  • Magnesium / metabolism*
  • Magnesium Compounds / chemistry*
  • Materials Testing
  • Nanoparticles / chemistry*
  • Particle Size
  • Surface Properties

Substances

  • Coated Materials, Biocompatible
  • Magnesium Compounds
  • magnesium fluoride
  • Durapatite
  • Magnesium
  • Fluorides
  • Calcium