Caveolae: Formation, dynamics, and function

Robert G Parton; Kerrie-Ann McMahon; Yeping Wu

doi:10.1016/j.ceb.2020.02.001

Caveolae: Formation, dynamics, and function

Curr Opin Cell Biol. 2020 Aug:65:8-16. doi: 10.1016/j.ceb.2020.02.001. Epub 2020 Mar 6.

Authors

Robert G Parton¹, Kerrie-Ann McMahon², Yeping Wu³

Affiliations

¹ The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia; The University of Queensland, Centre for Microscopy and Microanalysis, Brisbane, Queensland, 4072, Australia. Electronic address: [email protected].
² The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia. Electronic address: [email protected].
³ The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia.

PMID: 32146331
DOI: 10.1016/j.ceb.2020.02.001

Abstract

Caveolae are abundant surface pits formed by the assembly of cytoplasmic proteins on a platform generated by caveolin integral membrane proteins and membrane lipids. This membranous assembly can bud off into the cell or can be disassembled releasing the cavin proteins into the cytosol. Disassembly can be triggered by increased membrane tension, or by stress stimuli, such as UV. Here, we discuss recent mechanistic studies showing how caveolae are formed and how their unique properties allow them to function as multifunctional protective and signaling structures.

Keywords: Caveolae; Caveolin; Cavin; EHD2; Lipid; Membrane traffic.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Caveolae / metabolism*
Humans
Membrane Lipids / metabolism
Membrane Proteins / metabolism
Models, Biological
Signal Transduction
Stress, Physiological

Substances

Membrane Lipids
Membrane Proteins