Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

Ning Wang; Boshen Wang; Jiadi Guo; Suhao Zhang; Lei Han; Juan Zhang; Baoli Zhu

doi:10.1155/2020/9589310

Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

Biochem Res Int. 2020 Feb 17:2020:9589310. doi: 10.1155/2020/9589310. eCollection 2020.

Authors

Ning Wang^{1

2}, Boshen Wang^{1

2}, Jiadi Guo^{2

3}, Suhao Zhang⁴, Lei Han², Juan Zhang¹, Baoli Zhu^{1

2

3}

Affiliations

¹ Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China.
² Jiangsu ProvincialCenter for Disease Prevention and Control, Nanjing 210009, Jiangsu, China.
³ Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, Jiangsu, China.
⁴ School of Public Health, NantongUniversity, Nantong 226000, Jiangsu, China.

Abstract

Objectives: The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

Methods: We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

Results: We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5. Conclusion. The genetic polymorphism, rs11077, within XPO5 is associated with the risk of noise-induced hearing loss in a Chinese population.XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.