Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicited by PLU. Therefore, mice were pre-treated with GABAergic, serotonergic, adrenergic or dopaminergic receptor antagonists (i.p.), and exposed to Elevated Plus-Maze (EPM) and Open-Field Test (OFT). The preliminary results revealed that PLU (p.o.) possibly interacts with the mentioned systems through the GABA_A, GABA_B, 5-HT_1A, 5-HT₃, α₁, α₂, and D₂ receptors.