Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes

George W Mobbs; André Hoelz

doi:10.1016/j.tibs.2020.01.009

Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes

Trends Biochem Sci. 2020 Apr;45(4):278-280. doi: 10.1016/j.tibs.2020.01.009. Epub 2020 Feb 13.

Authors

George W Mobbs¹, André Hoelz²

Affiliations

¹ Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
² Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Electronic address: [email protected].

Abstract

Oocytes stockpile nuclear pore complexes (NPCs) in cytoplasmic membrane sheets called annulate lamellae (AL) in preparation for rapid cell cycles during embryogenesis. Recently, Hampoelz et al. reported that AL-NPC assembly depends on the coordinated formation, transport, and interaction of biomolecular condensates containing distinct sets of nucleoporins.

Keywords: annulate lamellae; macromolecular assembly; nuclear pore complex; nucleoporin liquid–liquid phase separation condensate; oogenesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Nuclear Envelope
Nuclear Pore Complex Proteins*
Nuclear Pore*
Oocytes
Oogenesis

Substances

Nuclear Pore Complex Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding