Right-lateralized fronto-parietal network and phasic alertness in healthy aging

Sci Rep. 2020 Mar 16;10(1):4823. doi: 10.1038/s41598-020-61844-z.

Abstract

Phasic alerting cues temporarily increase the brain's arousal state. In younger and older participants, visual processing speed in a whole report task, estimated based on the theory of visual attention, is higher in cue than no-cue conditions. The present study assessed whether older participants' ability to profit from warning cues is related to intrinsic functional connectivity (iFC) in the cingulo-opercular and/or right fronto-parietal network. We acquired resting-state functional magnetic resonance imaging data from 31 older participants. By combining an independent component analysis and dual regression, we investigated iFC in both networks. A voxel-wise multiple regression in older participants yielded that higher phasic alerting effects on visual processing speed were significantly related to lower right fronto-parietal network iFC. This result supports a particular role of the right fronto-parietal network in maintaining phasic alerting capabilities in aging. We then compared healthy older participants to a previously reported sample of healthy younger participants to assess whether behaviour-iFC relationships are age group specific. The comparison revealed that the association between phasic alerting and cingulo-opercular network iFC is significantly lower in older than in younger adults.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arousal
  • Attention*
  • Cues
  • Female
  • Frontal Lobe / diagnostic imaging
  • Frontal Lobe / physiology*
  • Functional Laterality / physiology*
  • Healthy Aging / physiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Nerve Net / diagnostic imaging
  • Nerve Net / physiology*
  • Parietal Lobe / diagnostic imaging
  • Parietal Lobe / physiology*
  • Reaction Time
  • Visual Perception / physiology
  • Young Adult