Is there a link between IL-23/IL-17 and developmental pathways such as the Wnt and Hedgehog pathway?

Nicholas Stamatis-Liossis; Dimitrios Daoussis; ASSOCIATED CENTRES/CLINICS; Alexandros Drosos; Lazaros Sakkas

doi:10.31138/mjr.28.1.59

Is there a link between IL-23/IL-17 and developmental pathways such as the Wnt and Hedgehog pathway?

Mediterr J Rheumatol. 2017 Mar 28;28(1):59-61. doi: 10.31138/mjr.28.1.59. eCollection 2017 Mar.

Authors

Nicholas Stamatis-Liossis¹, Dimitrios Daoussis¹; ASSOCIATED CENTRES/CLINICS; Alexandros Drosos², Lazaros Sakkas³

Affiliations

¹ University Department of Internal Medicine, Rheumatology Department, Rheumatology Research Laboratory, Medical University of Patras, Greece.
² Department of Rheumatology, Medical University of Ioannina.
³ Rheumatology Department, University Medical School of Larissa.

Abstract

Recent experimental evidence suggests that IL-23 may induce spondyloarthropathy by acting on entheseal resident "innate-like" T cells. These cells express IL-23R and respond to IL-23 by secreting inflammatory cytokines such as IL-6 and IL-17 as well as IL-22 which acts on osteoblasts and regulates bone remodeling. Moreover, a large amount of evidence indicates that new bone formation in the form of osteophytes is mainly driven by reactivation of developmental pathways such as the Wnt and the Hedgehog pathway. We hypothesize that IL-23/IL-17 may mediate bone remodeling by affecting the expression of developmental pathways.

Keywords: Hedgehog; IL-17; IL-23; Wnt; ankylosing spondylitis; pathways.