Bromodomain AAA+ ATPases get into shape

Magdalena Murawska; Andreas G Ladurner

doi:10.1080/19491034.2020.1741304

Bromodomain AAA+ ATPases get into shape

Nucleus. 2020 Dec;11(1):32-34. doi: 10.1080/19491034.2020.1741304.

Authors

Magdalena Murawska¹, Andreas G Ladurner¹

Affiliation

¹ Biomedical Center, Physiological Chemistry, Ludwig-Maximilians-University of Munich, Planegg-Martinsried, Germany.

Abstract

Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.

Keywords: Abo1; bromodomain AAA+ ATPase; histone chaperone.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

ATPases Associated with Diverse Cellular Activities / chemistry*
ATPases Associated with Diverse Cellular Activities / metabolism*
Cryoelectron Microscopy
Humans
Models, Molecular

Substances

ATPases Associated with Diverse Cellular Activities

Grants and funding

This work was supported by the Friedrich-Baur-Stiftung; H2020 European Research Council [H2020-MSC-I-2014-657244]; DFG [SFB1064]; DFG [SFB1309-325871075].