Abstract
New compounds containing 5,6-dihydro imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro imidazo[2,1-b]thiazole and 2,3-dihydro imidazo[2,1-b]benzothiazole rings, substituted by heterocycles analogue to chromones, were synthesized and screened against three nematodes, in vitro. The results indicate moderate anthelmintic properties, compared to levamisole; nevertheless, some products exhibit a significant degree of activity.
MeSH terms
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Animals
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Anthelmintics / chemical synthesis*
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Chemical Phenomena
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Chemistry
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Filarioidea / drug effects
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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In Vitro Techniques
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Levamisole / analogs & derivatives*
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Levamisole / chemical synthesis
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Levamisole / pharmacology
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Mitochondria, Liver / enzymology
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Nematoda / drug effects
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Nippostrongylus / drug effects
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Rats
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Succinate Dehydrogenase / antagonists & inhibitors
Substances
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Anthelmintics
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Imidazoles
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Levamisole
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Succinate Dehydrogenase