[Dihydro-5,6-imidazo[2,1-b]thiazoles, dihydro-2,3-imidazo[2,1-b]benzothiazoles, analogs of levamisole]

Farmaco Sci. 1988 May;43(5):421-37.
[Article in French]

Abstract

New compounds containing 5,6-dihydro imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro imidazo[2,1-b]thiazole and 2,3-dihydro imidazo[2,1-b]benzothiazole rings, substituted by heterocycles analogue to chromones, were synthesized and screened against three nematodes, in vitro. The results indicate moderate anthelmintic properties, compared to levamisole; nevertheless, some products exhibit a significant degree of activity.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Anthelmintics / chemical synthesis*
  • Chemical Phenomena
  • Chemistry
  • Filarioidea / drug effects
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • In Vitro Techniques
  • Levamisole / analogs & derivatives*
  • Levamisole / chemical synthesis
  • Levamisole / pharmacology
  • Mitochondria, Liver / enzymology
  • Nematoda / drug effects
  • Nippostrongylus / drug effects
  • Rats
  • Succinate Dehydrogenase / antagonists & inhibitors

Substances

  • Anthelmintics
  • Imidazoles
  • Levamisole
  • Succinate Dehydrogenase