A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development

David S Lorberbaum; Lori Sussel

doi:10.1016/j.devcel.2020.02.018

A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development

Dev Cell. 2020 Mar 23;52(6):681-682. doi: 10.1016/j.devcel.2020.02.018.

Authors

David S Lorberbaum¹, Lori Sussel²

Affiliations

¹ Barbara Davis Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
² Barbara Davis Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: [email protected].

PMID: 32208161
DOI: 10.1016/j.devcel.2020.02.018

Abstract

Notch signaling is a major regulator of pancreas development, yet how it precisely controls pancreatic cell fates has remained obscure. Seymour et al. (2020) use sophisticated Notch- based genetic tools to uncover highly context- and temporally-specific roles for DLL1, JAG1, and HES1 in regulating pancreatic progenitor cell growth and specification.

Publication types

Comment

MeSH terms

Cell Differentiation
Pancreas
Receptors, Notch*
Signal Transduction*
Spatio-Temporal Analysis

Substances

Receptors, Notch

Grants and funding

R01 DK082590/DK/NIDDK NIH HHS/United States