Combined Diagnosis of Whole-Lesion Histogram Analysis of T1- and T2-Weighted Imaging for Differentiating Adrenal Adenoma and Pheochromocytoma: A Support Vector Machine-Based Study

Purpose: This study aimed to determine whether a combined diagnosis of whole-lesion histogram analysis of T1- and T2-weighted imaging based on support vector machine (SVM) can distinguish pheochromocytoma from adrenal adenoma.

Methods: A pathology database was retrospectively appraised over a period of 7 years and we obtained 40 histopathologically proven adrenal adenomas and 20 pheochromocytomas with magnetic resonance images. The T1-weighted imaging (T₁WI, including both in phase and opposed phase) and T2-weighted imaging (T₂WI) images of each patients were analyzed using Mazda software. Nine parameters were selected as indicators of comparison: variance, skewness, kurtosis, mean, 1st percentile, 10th percentile, 50th percentile, 90th percentile, and 99th percentile. The parameters with differential-diagnosis significance were used to establish the combined diagnostic model of SVM.

Results: Among the 9 parameters extracted using histogram analysis, the 1st percentile, 10th percentile, and 50th percentile of T₁WI (in phase) and the skewness of T₂WI and almost all parameters of T₁WI (opposed phase), except variance and 99th percentile, showed statistical significance between groups. Among the above parameters, the area under the curve (AUC) of 10th percentile of T₁WI (opposed phase) was the largest with the value of 0.909 (100.0% sensitivity and 80.0% specificity). After the analysis of combined diagnosis was performed, the AUC of SVM model in testing set showed the value of 0.917 (85.0% accuracy).

Conclusions: Whole-lesion histogram analysis of T₁WI and T₂WI may help differentiate adrenal adenomas from pheochromocytomas. Furthermore, the combined diagnosis of T₁WI and T₂WI histogram based on SVM was more effective than most of individual histogram parameters.