Abstract
Five derivatives of 2-(3-aminopropionyl)-1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carboline (2a-e) were obtained, which yielded, as a result of reduction with LiAlH4, five respective 2-aminopropyl-derivatives (3a-e). Pharmacological studies revealed that phenylpiperazine-derivatives 2d, 2e, 3d and 3e have sedative and analgesic properties. All compounds are devoided of neuroleptic, antidepressant, anxiolytic and antiparkinsonic activity.
MeSH terms
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Analgesics*
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Animals
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Behavior, Animal / drug effects
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Carbolines / chemical synthesis
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Carbolines / pharmacology*
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Carbolines / toxicity
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Drug Evaluation, Preclinical
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Hypnotics and Sedatives*
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Pain Measurement
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Propylamines / chemical synthesis
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Propylamines / pharmacology
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Propylamines / toxicity
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Pyridines / chemical synthesis
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Pyridines / pharmacology*
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Pyridines / toxicity
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Structure-Activity Relationship
Substances
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Analgesics
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Carbolines
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Hypnotics and Sedatives
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Propylamines
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Pyridines