Abstract
Ten cyclic animals (1-10), including a form of decahydro-5H-pyrido [1',2';5,1] imidazo [3,4-a]-beta-carboline, were obtained by treating erythro 1-(2'-piperidyl)-1,2,3,4-tetrahydro-beta-carboline with aldehydes. The anticonvulsant action of those compounds (1-10) was investigated in mice using a behavioral test. Only 5-(3-chlorophenyl) (2) and 5-(3-pyridyl) (9) derivatives showed an anticonvulsant activity in the electric seizure test, but their therapeutic index was inferior to that of phenytoin.
MeSH terms
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Animals
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Anticonvulsants*
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Carbolines / chemical synthesis
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Carbolines / pharmacology*
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Carbolines / toxicity
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Drug Evaluation, Preclinical
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Electroshock
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Imidazoles / chemical synthesis
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Imidazoles / pharmacology
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Imidazoles / toxicity
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Pentylenetetrazole
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Phenytoin / pharmacology
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Pyridines / chemical synthesis
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Pyridines / pharmacology*
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Pyridines / toxicity
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Seizures / etiology
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Seizures / prevention & control
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Structure-Activity Relationship
Substances
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Anticonvulsants
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Carbolines
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Imidazoles
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Pyridines
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Phenytoin
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Pentylenetetrazole