NUCB2/nesfatin-1 - Inhibitory effects on food intake, body weight and metabolism

Peptides. 2020 Jun:128:170308. doi: 10.1016/j.peptides.2020.170308. Epub 2020 Mar 27.

Abstract

Since its discovery in 2006 by Oh-I and colleagues, NUCB2/nesfatin-1 encoded by nucleobindin-2 (NUCB2) has drawn sustained attention as reflected in over 500 publications. Among those, more than half focused on the alterations of food intake, body weight and metabolism (glucose, fat) induced by nesfatin-1 and/or NUCB2/nesfatin-1. In the current review we discuss the existing literature focusing on NUCB2/nesfatin-1's influence on food intake, body weight and glucose as well as fat metabolism and highlight gaps in knowledge.

Keywords: Anorexigenic; Blood glucose; Body weight; Fat; Food intake; Gut-brain axis; Hypothalamus; Insulin; Obesity; Satiety.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Body Weight / drug effects*
  • Eating / drug effects*
  • Fats / metabolism
  • Glucose / metabolism
  • Humans
  • Hypothalamus / drug effects
  • Hypothalamus / metabolism
  • Nucleobindins / metabolism*
  • Nucleobindins / pharmacology*

Substances

  • Fats
  • NUCB2 protein, human
  • Nucb2 protein, mouse
  • Nucb2 protein, rat
  • Nucleobindins
  • Glucose

Grants and funding