Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation

Circ J. 2020 Apr 24;84(5):825-829. doi: 10.1253/circj.CJ-19-0955. Epub 2020 Mar 31.

Abstract

Background: Angiotensin (Ang)I is cleaved by angiotensin-converting enzyme (ACE) to generate AngII. The purpose of this study was to determine the roles of ACE in endothelial and smooth muscle cells in aortic aneurysms.

Methods and results: AngI infusion led to thoracic and abdominal aortic aneurysms in low-density lipoprotein receptor-deficient mice, which were ablated by ACE inhibition. Endothelial or smooth muscle cell-specific ACE deletion resulted in reduction of AngI-induced thoracic, but not abdominal, aortic dilatation.

Conclusions: AngI infusion causes thoracic and abdominal aortic aneurysms in mice. ACE in aortic resident cells has differential effects on AngI-induced thoracic and abdominal aortic aneurysms.

Keywords: Angiotensin; Angiotensin-converting enzyme; Aortic aneurysm; Endothelial cells; Smooth muscle cells.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Angiotensin I*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Animals
  • Aorta, Abdominal / drug effects
  • Aorta, Abdominal / enzymology*
  • Aorta, Abdominal / pathology
  • Aorta, Thoracic / drug effects
  • Aorta, Thoracic / enzymology*
  • Aorta, Thoracic / pathology
  • Aortic Aneurysm, Abdominal / chemically induced
  • Aortic Aneurysm, Abdominal / enzymology*
  • Aortic Aneurysm, Abdominal / pathology
  • Aortic Aneurysm, Abdominal / prevention & control
  • Aortic Aneurysm, Thoracic / chemically induced
  • Aortic Aneurysm, Thoracic / enzymology*
  • Aortic Aneurysm, Thoracic / pathology
  • Aortic Aneurysm, Thoracic / prevention & control
  • Dilatation, Pathologic
  • Disease Models, Animal
  • Endothelial Cells / enzymology
  • Endothelial Cells / pathology
  • Mice, Knockout
  • Myocytes, Smooth Muscle / enzymology
  • Myocytes, Smooth Muscle / pathology
  • Peptidyl-Dipeptidase A / deficiency
  • Peptidyl-Dipeptidase A / genetics
  • Peptidyl-Dipeptidase A / metabolism*
  • Receptors, LDL / deficiency
  • Receptors, LDL / genetics

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Receptors, LDL
  • Angiotensin I
  • Peptidyl-Dipeptidase A