Prognosis of Hepatic Encephalopathy

Anita Krishnarao; Fredric D Gordon

doi:10.1016/j.cld.2020.01.004

Prognosis of Hepatic Encephalopathy

Clin Liver Dis. 2020 May;24(2):219-229. doi: 10.1016/j.cld.2020.01.004. Epub 2020 Mar 2.

Authors

Anita Krishnarao¹, Fredric D Gordon²

Affiliations

¹ Division of Transplantation and Hepatobiliary Diseases, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805, USA.
² Division of Transplantation and Hepatobiliary Diseases, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805, USA; Tufts Medical School, 145 Harrison Avenue, Boston, MA 02111, USA. Electronic address: [email protected].

PMID: 32245529
DOI: 10.1016/j.cld.2020.01.004

Abstract

The presence of hepatic encephalopathy is often associated with worse clinical outcomes and increased mortality. Even subclinical hepatic encephalopathy has clinical impacts on daily life and has been linked to increased falls, motor vehicle accidents, and hospitalizations. The presence and degree of hepatic encephalopathy can also affect survival outcomes in cirrhosis, acute liver failure, and liver transplant recipients. Patients may have improved clinical outcomes after treatment of hepatic encephalopathy, but the long-term impact of treatment on prognosis is unclear.

Keywords: Decompensation; Encephalopathy; Hospitalization; Prognosis; Survival.

Publication types

Review

MeSH terms

Asymptomatic Diseases
Hepatic Encephalopathy* / drug therapy
Hepatic Encephalopathy* / etiology
Humans
Liver Cirrhosis* / complications
Liver Cirrhosis* / physiopathology
Liver Cirrhosis* / surgery
Liver Transplantation / adverse effects
Postoperative Period
Preoperative Period
Prognosis
Risk Factors
Survival Rate