Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice

Chen Yang; Zhenxia Xu; Qianchun Deng; Qingde Huang; Xu Wang; Fenghong Huang

doi:10.1016/j.foodres.2020.108994

Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice

Food Res Int. 2020 May:131:108994. doi: 10.1016/j.foodres.2020.108994. Epub 2020 Jan 10.

Authors

Chen Yang¹, Zhenxia Xu², Qianchun Deng², Qingde Huang², Xu Wang³, Fenghong Huang⁴

Affiliations

¹ Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, No. 2 Xudong 2nd Road, Wuhan 430062, China. Electronic address: [email protected].
² Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, No. 2 Xudong 2nd Road, Wuhan 430062, China.
³ Huazhong Agricultural University, No.1 Shizishan Street, Wuhan 430070, China.
⁴ Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, No. 2 Xudong 2nd Road, Wuhan 430062, China; Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences, 202, Gongye North Road, Jinan 250100, China.

PMID: 32247451
DOI: 10.1016/j.foodres.2020.108994

Abstract

Flaxseed (Linum usitatissimum L.) is known as healthy food for its anti-obesity and lipid modulating properties. However, the effects of flaxseed polysaccharide (FSP) on metabolic syndrome (MetS) and gut microbiota are still poorly understood. Here, we investigated the effects of FSP on lipid metabolism and gut microbiota in high-fat-diet-fed mice. FSP effectively reduced the serum fasting glucose, total triglyceride and total cholesterol levels. FSP consumption adipose accumulation impacted the gut microbiome at different taxonomic levels by increasing the proportions of beneficial Akkermansia and Bifidobacterium and decreasing the disease or obesity associated Oscillospira and Odoribacteraceae. These changes were highly correlated with the regulation of expression levels of lipid metabolism involved genes in the liver. The restoration of total SCFAs, especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders. These findings suggest that FSP may use as a prebiotic for preventing MetS by modulating the gut microbiota.

Keywords: Akkermansia; Flaxseed polysaccharides; Gut microbiota; Metabolic syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Akkermansia / drug effects
Animals
Bifidobacterium / drug effects
Diet, High-Fat / adverse effects*
Flax / chemistry*
Gastrointestinal Microbiome / drug effects*
Gene Expression Regulation / drug effects
Glucose Intolerance
Lipid Metabolism
Male
Metabolic Syndrome / chemically induced
Metabolic Syndrome / diet therapy*
Mice
Polysaccharides / chemistry
Polysaccharides / pharmacology*

Substances

Polysaccharides