Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2

Org Lett. 2020 May 1;22(9):3570-3575. doi: 10.1021/acs.orglett.0c01014. Epub 2020 Apr 7.

Abstract

An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac)2 (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac)2 differentiating reduction process of reaction partners.