The absolute response of the GE Amersham Typhoontm imaging plate scanner is studied in this paper. The sensitivity function of the scanner with different photomultiplier tube voltages was obtained by using a pre-calibrated Cu Kα x-ray tube. The results showed that the sensitivity function decreases exponentially with higher voltage and is also affected by the scanning pixel size. The spatial resolution and the fading effect of the imaging plate system on x rays were also investigated and compared with the previous scanner models.