A novel immunosuppression-based classification of liver tumors opens new perspectives for adapted therapeutic strategies

EBioMedicine. 2020 Apr:54:102737. doi: 10.1016/j.ebiom.2020.102737. Epub 2020 Apr 5.
No abstract available

MeSH terms

  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Antineoplastic Agents, Immunological / therapeutic use*
  • B7-H1 Antigen / antagonists & inhibitors
  • B7-H1 Antigen / genetics
  • B7-H1 Antigen / immunology
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / genetics
  • Carcinoma, Hepatocellular / immunology
  • Carcinoma, Hepatocellular / pathology
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Genome, Human
  • Humans
  • Immunotherapy, Adoptive / methods
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / genetics
  • Liver Neoplasms / immunology
  • Liver Neoplasms / pathology
  • Phenylurea Compounds / therapeutic use
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • Programmed Cell Death 1 Receptor / genetics
  • Programmed Cell Death 1 Receptor / immunology
  • Pyrazoles / therapeutic use
  • Quinolines / therapeutic use
  • Sunitinib / therapeutic use
  • T-Lymphocytes, Regulatory / cytology
  • T-Lymphocytes, Regulatory / drug effects
  • T-Lymphocytes, Regulatory / immunology
  • Transforming Growth Factor beta / antagonists & inhibitors
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / immunology
  • Tumor-Associated Macrophages / cytology
  • Tumor-Associated Macrophages / drug effects
  • Tumor-Associated Macrophages / immunology

Substances

  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents, Immunological
  • B7-H1 Antigen
  • CD274 protein, human
  • PDCD1 protein, human
  • Phenylurea Compounds
  • Programmed Cell Death 1 Receptor
  • Pyrazoles
  • Quinolines
  • Transforming Growth Factor beta
  • LY-2157299
  • lenvatinib
  • avelumab
  • Sunitinib