Visual field fluctuations correlating with the menstrual cycle in a patient with optic pathway glioma

Adam Jacobson; Marcia Leonard; Patricia Robertson; Brenda L Bohnsack

doi:10.1136/bcr-2019-234014

Visual field fluctuations correlating with the menstrual cycle in a patient with optic pathway glioma

BMJ Case Rep. 2020 Apr 7;13(4):e234014. doi: 10.1136/bcr-2019-234014.

Authors

Adam Jacobson¹, Marcia Leonard², Patricia Robertson², Brenda L Bohnsack³

Affiliations

¹ Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, USA.
² Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
³ Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, USA [email protected].

Abstract

Optic pathway gliomas are commonly associated with vision loss in children. We describe an 18-year-old woman with neurofibromatosis, type 1 and an optic nerve glioma who showed reproducible visual field defects that worsened midmenstrual cycle and returned to baseline during menses. To our knowledge, this is the first reported case of visual field fluctuations in a patient with an optic nerve glioma that correlated with her menstrual cycle.

Keywords: CNS cancer; neurooncology; visual pathway.

Publication types

Case Reports

MeSH terms

Adolescent
Female
Humans
Immunologic Factors / therapeutic use
Lenalidomide / therapeutic use
Menstrual Cycle*
Neurofibromatosis 1 / drug therapy
Neurofibromatosis 1 / physiopathology*
Optic Nerve Glioma / drug therapy
Optic Nerve Glioma / physiopathology*
Vision Disorders / drug therapy
Vision Disorders / physiopathology*
Visual Fields*

Substances

Immunologic Factors
Lenalidomide