Abstract
Herein, we have successfully semi-synthesized a TDP-43 prion-like domain with Ser404 phosphorylation. We have demonstrated that Ser404 phosphorylation could accelerate the amyloid aggregation of the TDP-43 prion-like domain and aggravate its cytotoxicity.
MeSH terms
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Amyloidogenic Proteins / chemical synthesis
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Amyloidogenic Proteins / metabolism
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Amyloidogenic Proteins / pharmacology*
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Amyloidogenic Proteins / toxicity
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Animals
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Cell Line, Tumor
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DNA-Binding Proteins / chemical synthesis
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DNA-Binding Proteins / metabolism
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DNA-Binding Proteins / pharmacology*
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DNA-Binding Proteins / toxicity
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Mice
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Peptide Fragments / chemical synthesis
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Peptide Fragments / metabolism
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Peptide Fragments / pharmacology*
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Peptide Fragments / toxicity
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Phosphorylation
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Prion Proteins / chemical synthesis
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Prion Proteins / metabolism
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Prion Proteins / pharmacology*
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Prion Proteins / toxicity
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Protein Domains
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Protein Multimerization
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Serine / chemistry*
Substances
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Amyloidogenic Proteins
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DNA-Binding Proteins
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Peptide Fragments
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Prion Proteins
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Serine