Abstract
Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.
MeSH terms
-
Animals
-
Cell Proliferation
-
Coculture Techniques
-
Disease Models, Animal
-
Durapatite / chemistry*
-
Durapatite / therapeutic use
-
Exosomes / metabolism*
-
Magnetite Nanoparticles / chemistry*
-
Magnetite Nanoparticles / therapeutic use
-
Osteoblasts / cytology*
-
Osteoblasts / metabolism
-
Osteoclasts / metabolism*
-
Osteoporosis / pathology*
-
Osteoporosis / therapy
-
Rats
-
Tissue Scaffolds / chemistry*
Substances
-
Magnetite Nanoparticles
-
Durapatite