Abstract
The Ru(ii) complex of an imidazole-mesalazine Schiff base is a unique example showing growth inhibition of 3D-colon cancer stem cell spheroids and bulk colon cancer cells at lower dosage than salinomycin or oxaliplatin. Unlike oxaliplatin which increases the expression of stemness genes (SOX2, KLF4, HES1 and Oct4), these complexes maintain a tight regulation.
MeSH terms
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Aminosalicylic Acids / chemistry
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Aminosalicylic Acids / pharmacology*
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Aminosalicylic Acids / toxicity
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / toxicity
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Apoptosis / drug effects
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Cell Line, Tumor
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Coordination Complexes / toxicity
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Cymenes / chemistry
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Cymenes / pharmacology*
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Cymenes / toxicity
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Drug Screening Assays, Antitumor
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Drug Stability
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G2 Phase Cell Cycle Checkpoints / drug effects
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Humans
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Kruppel-Like Factor 4
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Ligands
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Neoplastic Stem Cells / drug effects*
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Ruthenium / chemistry
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Spheroids, Cellular / drug effects*
Substances
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Aminosalicylic Acids
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Antineoplastic Agents
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Coordination Complexes
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Cymenes
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KLF4 protein, human
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Kruppel-Like Factor 4
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Ligands
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4-cymene
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Ruthenium