Linking mitochondria to the immune response

Rebecca L Wallings; Mary K Herrick; Malú Gámez Tansey

doi:10.7554/eLife.56214

Linking mitochondria to the immune response

Elife. 2020 Apr 15:9:e56214. doi: 10.7554/eLife.56214.

Authors

Rebecca L Wallings^{1

2}, Mary K Herrick^{1

2}, Malú Gámez Tansey^{1

2}

Affiliations

¹ Department for Neuroscience, University of Florida College of Medicine, Gainesville, United States.
² Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, United States.

Abstract

A gene associated with Parkinson's disease regulates mitochondrial homeostasis, thus affecting innate immunity.

Keywords: DRP1; Parkinson's disease; bacterial pathogenesis; cGAS; human; immunology; infectious disease; inflammation; metabolism; microbiology; mouse; purine biosynthesis.

Publication types

Comment

MeSH terms

Homeostasis
Humans
Immunity, Innate
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mitochondria / genetics
Mycobacterium tuberculosis*
Parkinson Disease*

Substances

LRRK2 protein, human
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Grants and funding

T32 NS096050/NS/NINDS NIH HHS/United States