Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency

Signal Transduct Target Ther. 2020 Apr 1;5(1):30. doi: 10.1038/s41392-020-0143-9.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Lymphoma / drug therapy*
  • Lymphoma / genetics
  • Lymphoma / pathology
  • Piperidones / pharmacology
  • Tumor Suppressor Protein p53 / deficiency
  • Tumor Suppressor Protein p53 / genetics*
  • Ubiquitin Thiolesterase / genetics*

Substances

  • 3,5-bis((4-nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one
  • Piperidones
  • Trp53 protein, mouse
  • Tumor Suppressor Protein p53
  • Usp14 protein, mouse
  • Ubiquitin Thiolesterase
  • Uchl5 protein, mouse