Graves' disease could increase polycystic ovary syndrome and comorbidities in Taiwan

Hsin-Hung Chen; Ching-Chu Chen; Ming-Chia Hsieh; Chun-Wei Ho; Sheng-Pang Hsu; Hei-Tung Yip; Chia-Hung Kao

doi:10.1080/03007995.2020.1756235

Graves' disease could increase polycystic ovary syndrome and comorbidities in Taiwan

Curr Med Res Opin. 2020 Jun;36(6):1063-1067. doi: 10.1080/03007995.2020.1756235. Epub 2020 Apr 28.

Authors

Hsin-Hung Chen^{1

2}, Ching-Chu Chen^{3

4}, Ming-Chia Hsieh^{1

5

6}, Chun-Wei Ho¹, Sheng-Pang Hsu³, Hei-Tung Yip^{7

8}, Chia-Hung Kao^{9

10

11

12}

Affiliations

¹ Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung, Taiwan.
² School of Medicine, Institute of Medicine and Public Health, Chung Shan Medical University, Taichung, Taiwan.
³ Division of Endocrinology and Metabolism, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
⁴ School of Chinese Medicine, China Medical University, Taichung, Taiwan.
⁵ Graduate Institute of Integrative Medicine, China Medical University, Taichung, Taiwan.
⁶ Division of Clinical Nutrition, China Medical University Hospital, Taichung, Taiwan.
⁷ Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
⁸ School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
⁹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
¹⁰ Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
¹¹ Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.
¹² Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung, Taiwan.

PMID: 32297812
DOI: 10.1080/03007995.2020.1756235

Abstract

Background: To investigate the association between Graves' disease (GD) and polycystic ovary syndrome (PCOS) and its comorbidities.Methods: Logistic regression was performed to determine the association between the two conditions. Cumulative incidence curves were obtained using the Kaplan-Meier method and log-rank test. Hazard ratios were determined using the Cox proportional hazards regression model.Results: We included 5399 patients with GD as the study group and 10,798 patients without GD as the control group. The cumulative incidence curve of PCOS in patients with GD was significantly higher than that in patients without GD (p = .02). The adjusted hazard ratio for PCOS in patients with GD compared with patients without GD was 1.47 (95%CI = 1.09-1.98). The adjusted odds ratio of hyperlipidemia in patients with GD and PCOS was 2.18 (95%CI = 1.14-4.17) higher than that in patients with GD only.Conclusion: Our study demonstrated that women with GD could be at risk of developing PCOS; additionally, a higher incidence of comorbidities, including hyperlipidemia, was noted in women with GD and PCOS.

Keywords: Graves’ disease (GD); hyperlipidemia; polycystic ovary syndrome (PCOS).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Comorbidity
Female
Graves Disease / complications*
Graves Disease / epidemiology
Humans
Incidence
Logistic Models
Polycystic Ovary Syndrome / epidemiology*
Polycystic Ovary Syndrome / etiology
Proportional Hazards Models
Risk Factors