Dynamics of outcome after aneurysmal subarachnoid hemorrhage

Aging (Albany NY). 2020 Apr 20;12(8):7207-7217. doi: 10.18632/aging.103069. Epub 2020 Apr 20.

Abstract

In this observational study, we analyzed and described the dynamics of the outcome after aneurysmal subarachnoid hemorrhage (SAH) in a collective of 203 cases. We detected a significant improvement of the mean aggregate modified Rankin Score (mRS) in every time interval from discharge to 6 months and up to 1 year. Every forth to fifth patient with potential of recovery (mRS 1-5) at discharge improved by 1 mRS point in the time interval from 6 month to 1 year (22.6%). Patients with mRS 3 at discharge had a remarkable late recovery rate (73.3%, p = 0.000085). Multivariate analysis revealed age ≤ 65 years (odds ratio 4.93; p = 0.0045) and "World Federation of Neurological Surgeons" (WFNS) grades I and II (odds ratio 4.77; p = 0.0077) as significant predictors of early improvement (discharge to 6 months). Absence of a shunting procedure (odds ratio 8.32; p = 0.0049) was a significant predictor of late improvement (6 months to 1 year), but not age ≤ 65 years (p = 0.54) and WFNS grades I and II (p = 0.92). Thus, late recovery (6 month to 1 year) is significant and independent from age and WFNS grade.

Keywords: aging; intracranial aneurysm; outcome; stroke; subarachnoid hemorrhage.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Female
  • Humans
  • Intracranial Aneurysm / physiopathology
  • Intracranial Aneurysm / rehabilitation*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Subarachnoid Hemorrhage / physiopathology
  • Subarachnoid Hemorrhage / rehabilitation*
  • Time Factors