Prevalence of priapism in individuals with sickle cell disease and implications on male sexual function

Einstein (Sao Paulo). 2020 Apr 22:18:eAO5070. doi: 10.31744/einstein_journal/2020AO5070. eCollection 2020.
[Article in English, Portuguese]

Abstract

Objective: To evaluate epidemiological aspects of priapism in patients with sickle cell disease, and these aspects impact on adult sexual function.

Methods: This was a cross-sectional study including individuals with sickle cell disease who were evaluated at a reference center for sickle cell. Participants completed a structured questionnaire about their sociodemographic characteristics and priapism events. Sexual function was assessed using validated two instruments, the Erection Hardness Score and one about the sex life satisfaction.

Results: Sixty-four individuals with median aged of 12 (7 to 28) years were interviewed. The prevalence of priapism was 35.9% (23/64). The earliest priapism episode occurred at 2 years of age and the latest at 42 years. The statistical projection was that 71.1% of individuals of the study would have at least one episode of priapism throughout life. Patients with episodes of priapism (10/23) had significantly worse erectile function Erection Hardness Score of 2 [1-3]; p=0.01 and were less satisfied with sexual life 3 [3-5]; p=0.02.

Conclusion: Priapism is usually present in childhood, and severe episodes are associated with cavernous damage, impairment in the quality of the erection, and lower sexual satisfaction.

Objetivo: Avaliar aspectos epidemiológicos do priapismo em pacientes com doença falciforme e o impacto desses aspectos na função sexual de adultos.

Métodos: Trata-se de estudo transversal, que incluiu indivíduos com doença falciforme acompanhados em um centro de referência. Os participantes responderam a um questionário estruturado acerca das características sociodemográficas e eventos de priapismo. A função sexual foi avaliada por meio de dois instrumentos validados, a Escala de Rigidez de Ereção e um sobre satisfação com a vida sexual.

Resultados: Foram entrevistados 64 indivíduos com média de idade de 12 (7-28) anos. A prevalência de priapismo foi de 35,9% (23/64). O episódio mais precoce ocorreu aos 2 anos de idade e o mais tardio, aos 42 anos. A projeção estatística foi de que 71,1% desses sujeitos teriam pelo menos um episódio de priapismo ao longo da vida. Pacientes adultos com episódios de priapismo (10/23) apresentaram função erétil significativamente pior Escala de Rigidez de Ereção de 2 [1-3]; p=0,01 e estavam menos satisfeitos com a vida sexual 3 [3-5]; p=0,02.

Conclusão: O priapismo manifesta-se desde a infância, e episódios graves estão associados a dano cavernoso, prejuízo na qualidade da ereção e menor satisfação sexual.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Anemia, Sickle Cell / epidemiology*
  • Anemia, Sickle Cell / physiopathology*
  • Brazil / epidemiology
  • Child
  • Cross-Sectional Studies
  • Disease-Free Survival
  • Erectile Dysfunction / epidemiology*
  • Erectile Dysfunction / physiopathology*
  • Humans
  • Male
  • Penile Erection / physiology
  • Prevalence
  • Priapism / epidemiology*
  • Priapism / etiology
  • Priapism / physiopathology*
  • Quality of Life
  • Retrospective Studies
  • Statistics, Nonparametric
  • Surveys and Questionnaires
  • Young Adult