Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma

Simona Citro; Alice Bellini; Alessandro Medda; Maria Elisa Sabatini; Marta Tagliabue; Francesco Chu; Susanna Chiocca

doi:10.3389/fcimb.2020.00143

Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma

Front Cell Infect Microbiol. 2020 Apr 8:10:143. doi: 10.3389/fcimb.2020.00143. eCollection 2020.

Authors

Simona Citro¹, Alice Bellini¹, Alessandro Medda¹, Maria Elisa Sabatini¹, Marta Tagliabue², Francesco Chu², Susanna Chiocca¹

Affiliations

¹ Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
² Division of Otolaryngology Head & Neck Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.

Abstract

P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ΔNp63α mRNA and protein levels.

Keywords: HPV; HPV16; head and neck cancer; head and neck carcinoma; p63.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alphapapillomavirus*
Head and Neck Neoplasms*
Humans
Oncogene Proteins, Viral* / genetics
Papillomaviridae / genetics
Papillomavirus Infections*
Squamous Cell Carcinoma of Head and Neck

Substances

Oncogene Proteins, Viral