Abstract
This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.
Copyright © 2020 Elsevier Ltd. All rights reserved.
MeSH terms
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Adenosine Monophosphate / administration & dosage
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Adenosine Monophosphate / analogs & derivatives
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Adenosine Monophosphate / chemistry
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Alanine / administration & dosage
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Alanine / analogs & derivatives
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Alanine / chemistry
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Antiviral Agents / administration & dosage*
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Antiviral Agents / chemistry*
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Aquatic Organisms / chemistry*
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Biological Products / administration & dosage*
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Biological Products / chemistry*
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COVID-19
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Chloroquine / administration & dosage
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Chloroquine / chemistry
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Coronavirus Infections / drug therapy
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Drug Compounding
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Humans
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Hydroxychloroquine / administration & dosage
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Hydroxychloroquine / chemistry
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Models, Molecular
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Pandemics
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Pneumonia, Viral / drug therapy
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Volatilization
Substances
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Antiviral Agents
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Biological Products
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remdesivir
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Adenosine Monophosphate
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Hydroxychloroquine
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Chloroquine
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Alanine