Association between intrahepatic cholestasis of pregnancy and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis

Hypertens Pregnancy. 2020 Aug;39(3):354-360. doi: 10.1080/10641955.2020.1758939. Epub 2020 Apr 24.

Abstract

Objective: To investigate the association between intrahepatic cholestasis of pregnancy (ICP) and the risk of gestational diabetes mellitus (GDM) and preeclampsia via meta-analysis.

Methods: Pooled odds ratio (OR) and confidence interval (CI) of GDM and preeclampsia for women with ICP were calculated using the fixed- or random-effects model.

Results: Women with ICP were more likely to have GDM (pooled OR = 2.19, 95% CI: 1.58, 3.03, I 2 = 88.25%) and preeclampsia (pooled OR = 2.58, 95% CI: 2.37, 2.81, I 2 = 0%) than women without ICP.

Conclusion: The present study supports the concept that ICP is associated with the risk of GDM and preeclampsia.

Keywords: Intrahepatic cholestasis of pregnancy; gestational diabetes; meta-analysis; preeclampsia.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Adult
  • Cholestasis, Intrahepatic / epidemiology*
  • Diabetes, Gestational / epidemiology*
  • Female
  • Humans
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Pregnancy Outcome
  • Risk

Supplementary concepts

  • Intrahepatic Cholestasis of Pregnancy