Downshifting nanoprobes with follicle stimulating hormone peptide fabrication for highly efficient NIR II fluorescent bioimaging guided ovarian tumor surgery

Peiyuan Wang; Suhua Jiang; Yang Li; Qiang Luo; Jinyan Lin; Lidan Hu; Lingling Fan

doi:10.1016/j.nano.2020.102198

Downshifting nanoprobes with follicle stimulating hormone peptide fabrication for highly efficient NIR II fluorescent bioimaging guided ovarian tumor surgery

Nanomedicine. 2020 Aug:28:102198. doi: 10.1016/j.nano.2020.102198. Epub 2020 Apr 23.

Authors

Peiyuan Wang¹, Suhua Jiang², Yang Li², Qiang Luo², Jinyan Lin², Lidan Hu³, Lingling Fan⁴

Affiliations

¹ Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, PR China; Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, PR China; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, PR China; Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, PR China.
² Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, PR China; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, PR China; Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, PR China.
³ Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Biochemistry and Molecular Biology, University of South China, Hengyang, PR China.
⁴ Department of Obstetrics and Gynecology of Shanghai Medical School, Fudan University, Shanghai, PR China; Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, PR China; Obstetrics and Gynecology Hospital, Fudan University, Shanghai, PR China. Electronic address: [email protected].

PMID: 32334101
DOI: 10.1016/j.nano.2020.102198

Abstract

Failure of intraoperative detection, early minimal lesion and microscopic residual tumor margins elimination causes metastatic diffusion and lethal recurrence. However, during surgical process, surgeons can only rely largely on palpation and visual examination. Intraoperative bioimaging with the aid of the second near-infrared fluorescent (NIR II FL) light has entered the surgical excision area to bridge the gap of preoperative bioimaging and intraoperative resection. Here, we demonstrate that the follicle-stimulating hormone peptide (FSHP) engineered NIR II downshifting nanoparticles (DSNPs@FSHP) selectively undergo efficient ovarian tumor targeting property. Owing to the special biocompatibility of nanoprobes, this strategy provided rapid body clearance and efficient tumor targeting with significantly tumor to background (T/B) ratio enhanced for surgical excision. Based on these, this strategy can successfully empower the detection and surgical removal for both ovarian tumor lesions and ovarian tumor margins by NIR II FL bioimaging.

Keywords: Body clearance; NIR II FL bioimaging; Targeting efficiency; Tumor surgery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Female
Follicle Stimulating Hormone / chemistry*
Humans
Nanoparticles / chemistry*
Optical Imaging / methods*
Ovarian Neoplasms / diagnostic imaging*
Ovarian Neoplasms / surgery*
Spectroscopy, Near-Infrared / methods*

Substances

Follicle Stimulating Hormone