Accumulating evidences have pointed out that neuroinflammation is involved in Parkinson's disease (PD) pathogenesis. Toll-like receptor 3 (TLR3), as a member of pattern-recognition receptors (PRRs), is known to play a pivotal role in inflammatory responses and immune responses. It was recently suggested that TLR3 was increased in the animal models of PD. The present study aimed to evaluate whether TLR3 gene (rs3775290) polymorphism was associated with PD susceptibility. We genotyped the single-nucleotide polymorphism (SNP) of TLR3 gene (rs3775290) using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) from 380 PD patients and 380 control subjects in Chinese Han population. Our data demonstrated that rs3775290 T allele carriers were associated with a reduced risk of PD between early-onset PD(EOPD)group and its healthy-matched control subgroup (OR = 0.571, 95 %CI = 0.366-0.891, P = 0.013 for TT + TC vs CC). Moreover, there were significant differences in genotype and allele distribution between EOPD group and the late-onset PD (LOPD) group (P = 0.024 and P = 0.008, respectively). Therefore, our study suggested a possible association between TLR3 (rs3775290) gene polymorphism and PD susceptibility, indicating that T allele of rs3775290 might be a protective factor for sporadic PD in Han Chinese population.
Keywords: Parkinson(’)s disease (PD); Single nucleotide polymorphism (SNP); Toll-like receptors 3 (TLR3).
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