Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of pancreas: a rare entity-worth to note

BMJ Case Rep. 2020 Apr 27;13(4):e234855. doi: 10.1136/bcr-2020-234855.

Abstract

Mixed adenocarcinoma with neuroendocrine tumour of pancreas has been reported infrequently and consists of both epithelial and neuroendocrine component. We encountered an 81-year-old male patient who presented with clinical features of painful progressive jaundice for 1 month. Contrast-enhanced CT abdomen reported a mass in the pancreatic head with dilated common bile duct and pancreatic duct. He underwent pancreatoduodenectomy and histopathological examination revealed two different tumours: ductal adenocarcinoma admixed with neuroendocrine tumour of pancreas. He received adjuvant chemotherapy, and at the end of 1-year follow-up, he has no recurrence. Here, we reported this rare malignancy of pancreas for which pancreatoduodenectomy was done and diagnosed on histopathology with immunohistochemistry.

Keywords: adenocarcinoma; mixed; neuroendocrine; pancreas; pancreatoduodenectomy.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / therapy*
  • Aged, 80 and over
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Humans
  • Male
  • Neuroendocrine Tumors / therapy*
  • Pancreatic Neoplasms / therapy*
  • Pancreaticoduodenectomy