HER2 Mutations in Non-Small Cell Lung Cancer: A Herculean Effort to Hit the Target

Cancer Discov. 2020 May;10(5):643-645. doi: 10.1158/2159-8290.CD-20-0225.

Abstract

Over the last two decades HER2 aberrations have been thoroughly investigated as potential therapeutic targets in advanced non-small cell lung cancer, with relatively modest results. Two articles published in this issue of Cancer Discovery further expand the knowledge on therapeutic exploitation of HER2 in lung cancer, addressing a large unmet medical need.See related article by Li et al., p. 674.See related article by Tsurutani et al., p. 688.

Publication types

  • Comment

MeSH terms

  • Carcinoma, Non-Small-Cell Lung* / drug therapy
  • Carcinoma, Non-Small-Cell Lung* / genetics
  • Cytotoxins
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics
  • Mutation
  • Receptor, ErbB-2 / genetics

Substances

  • Cytotoxins
  • ERBB2 protein, human
  • Receptor, ErbB-2