The Secret Life of lncRNAs: Conserved, yet Not Conserved

Harshita Sharma; Piero Carninci

doi:10.1016/j.cell.2020.04.012

The Secret Life of lncRNAs: Conserved, yet Not Conserved

Cell. 2020 Apr 30;181(3):512-514. doi: 10.1016/j.cell.2020.04.012.

Authors

Harshita Sharma¹, Piero Carninci²

Affiliations

¹ Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
² Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. Electronic address: [email protected].

PMID: 32359433
DOI: 10.1016/j.cell.2020.04.012

Abstract

Guo and colleagues discover a new layer of complexity to the lncRNA evolution where positionally conserved lncRNAs in human ESCs are broadly spliced and exported to the cytoplasm contrary to their mouse counterpart that are predominantly unspliced and nuclear retained. Distinct processing leads to species-specific lncRNA function in pluripotency maintenance.

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MeSH terms

Animals
Cell Nucleus
Cytoplasm
Humans
Mice
RNA, Long Noncoding* / genetics
Stem Cells

Substances

RNA, Long Noncoding