Higher Levels of Alcohol Use Are Associated With Latent Tuberculosis Infection in Adults Living With Human Immunodeficiency Virus

Sarah B Puryear; Robin Fatch; Brian Beesiga; Allen Kekibiina; Sara Lodi; Kara Marson; Nneka I Emenyonu; Winnie R Muyindike; Dalsone Kwarisiima; Judith A Hahn; Gabriel Chamie

doi:10.1093/cid/ciaa527

Higher Levels of Alcohol Use Are Associated With Latent Tuberculosis Infection in Adults Living With Human Immunodeficiency Virus

Clin Infect Dis. 2021 Mar 1;72(5):865-868. doi: 10.1093/cid/ciaa527.

Authors

Affiliations

¹ Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, USA.
² Center for AIDS Prevention Studies, University of California San Francisco, San Francisco, California, USA.
³ Department of Medicine, University of California San Francisco, San Francisco, California, USA.
⁴ Infectious Diseases Research Collaboration, Kampala, Uganda.
⁵ Mbarara University of Science and Technology, Mbarara, Uganda.
⁶ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

Abstract

We assessed associations between hazardous alcohol use and latent tuberculosis infection (LTBI) among adults living with human immunodeficiency virus (HIV) in Uganda. We compared tuberculin skin test positivity across medium, high, and very-high alcohol use levels, classified by AUDIT-C scores. In multivariable analysis, very high use was associated with LTBI (adjusted odds ratio 1.61, 95% confidence interval: 1.03-2.50).

Keywords: Africa; HIV; alcohol; latent TB infection; tuberculosis (TB).

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
HIV
HIV Infections* / complications
Humans
Interferon-gamma Release Tests
Latent Tuberculosis* / complications
Latent Tuberculosis* / epidemiology
Tuberculin Test
Uganda / epidemiology

Abstract

Publication types

MeSH terms

Grants and funding