OPA1 and Angiogenesis: Beyond the Fusion Function

Max-Hinderk Schuler; Adam L Hughes

doi:10.1016/j.cmet.2020.04.014

OPA1 and Angiogenesis: Beyond the Fusion Function

Cell Metab. 2020 May 5;31(5):886-887. doi: 10.1016/j.cmet.2020.04.014.

Authors

Max-Hinderk Schuler¹, Adam L Hughes²

Affiliations

¹ Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
² Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: [email protected].

PMID: 32375059
DOI: 10.1016/j.cmet.2020.04.014

Abstract

In this issue of Cell Metabolism, Herkenne et al. (2020) show that the mitochondrial fusion protein OPA1 promotes angiogenesis independent of its function in mitochondrial dynamics, identifying a key new therapeutic target to prevent vascular growth during development and tumor formation.

Publication types

Comment

MeSH terms

GTP Phosphohydrolases* / genetics
Mitochondria
Mitochondrial Dynamics*
Mitochondrial Proteins

Substances

Mitochondrial Proteins
GTP Phosphohydrolases

Abstract

Publication types

MeSH terms

Substances

Grants and funding