Synthesis and pharmacological properties of new N-aminoalkyl-2-pyrrolidinone derivatives

Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):173-82.

Abstract

The paper describes the mode of obtaining and physico-chemical properties of new 1-(beta-hydroxy-gamma-aminopropyl)-2-pyrrolidinone derivatives and their antiarrhythmic effect and the action on the circulatory system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia
  • Animals
  • Anti-Arrhythmia Agents / chemical synthesis*
  • Anti-Arrhythmia Agents / toxicity
  • Blood Pressure / drug effects
  • Chemical Phenomena
  • Chemistry, Physical
  • Electrocardiography
  • Lethal Dose 50
  • Male
  • Mice
  • Pyrrolidinones / chemical synthesis*
  • Pyrrolidinones / pharmacology
  • Pyrrolidinones / toxicity
  • Rats
  • Rats, Inbred Strains
  • Respiration / drug effects
  • Species Specificity

Substances

  • Anti-Arrhythmia Agents
  • Pyrrolidinones