Unwind and Relax: DDX3X RNA Helicase as a Critical Mediator of Cortical Neurogenesis

Blake Vuocolo; J Lloyd Holder Jr

doi:10.1016/j.neuron.2020.03.035

Unwind and Relax: DDX3X RNA Helicase as a Critical Mediator of Cortical Neurogenesis

Neuron. 2020 May 6;106(3):357-358. doi: 10.1016/j.neuron.2020.03.035.

Authors

Blake Vuocolo¹, J Lloyd Holder Jr²

Affiliations

¹ Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Department of Pediatrics, Division of Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, TX, USA.
² Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Department of Pediatrics, Division of Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, TX, USA. Electronic address: [email protected].

PMID: 32380046
DOI: 10.1016/j.neuron.2020.03.035

Abstract

In this issue of Neuron, Lennox et al. (2020) report the largest cohort of patients to date with DDX3X syndrome, discovering unique genotype-phenotype relationships that inform molecular pathogenesis. They then uncover unique roles of DDX3X in cortical neuron development and ribonucleoprotein granule formation.

Publication types

Comment

MeSH terms

DEAD-box RNA Helicases / genetics*
Fetal Development
Humans
Mutation
Neurogenesis*
RNA

Substances

RNA
DDX3X protein, human
DEAD-box RNA Helicases