De Novo Gene Variants and Familial Bipolar Disorder

JAMA Netw Open. 2020 May 1;3(5):e203382. doi: 10.1001/jamanetworkopen.2020.3382.

Claudio Toma^{1

2}, Alex D Shaw^{1

2}, Bronwyn J Overs¹, Philip B Mitchell^{3

4}, Peter R Schofield^{1

2}, Antony A Cooper^{5

6}, Janice M Fullerton^{1

2}

¹ Neuroscience Research Australia, Sydney, New South Wales, Australia.
² School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
³ School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
⁴ Black Dog Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia.
⁵ Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
⁶ St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

Abstract

This case-control study explores de novo candidate gene variants in 18 multiplex families with bipolar disorder.